Phytochemicals: Health Promotion and Therapeutic Potential

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Phytochemicals: Health Promotion and Therapeutic Potential is the seventh in a series representing the emerging science with respect to plant-based chemicals. Drawn from the proceedings at the Seventh International Phytochemical Conference, Phytochemicals: Health Promotion and Therapeutic Potential, the book contains chapters written by conference presenters along with those of additional invited authors whose research focuses on the biological activities and clinical outcomes associated with phytochemical consumption.

The book begins with a discussion of major research that has contributed to the widespread interest in phytochemicals and health promotion. This is followed by an exploration of the beneficial effects of polyphenols in healthy aging and against a host of illnesses and disorders, including cancer, cardiovascular disease, inflammation, and ulcers.

The contributors also examine various aspects of phytochemicals related to bone and brain health, obesity, and metabolic disease. The book concludes by presenting methodologies for assessing the bioavailability of carotenoids and offers additional insight into Momordica cochichinensis Spreng, a fruit not commonly known in the Western world and a rich source of lycopene and beta-carotene. While promising advancements have been made in this field, opportunities for progress still exist concerning bioavailability, efficacy, genomics, and synergistic mechanisms.

Published online Aug 6. PMID: Mark P. Address correspondence to Mark P. Mattson: Phone , Fax , Email: vog. This article has been cited by other articles in PMC. Keywords: Alzheimer's disease, curcumin, neurotrophic factor, nrf2, resveratrol, sirtuin.

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Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia. Life Sci. Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death. Free Radic Biol Med. Exercise and hormesis: activation of cellular antioxidant signaling pathway. Ann N Y Acad Sci. Biological properties of curcumin-cellular and molecular mechanisms of action. Food Sci. Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model.

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Resveratrol, a natural red wine polyphe-nol, reduces ischemia-reperfusion-induced spinal cord injury. Ann Thorac Surg. Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. J Neurosci. Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease.

J Neurosci Res. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.

Neuromolecular Med. Phosphorylation of cAMP response element-binding protein in hip-pocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo. Curr Biol.

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How protein kinase C activation protects nerve cells from oxidative stress-induced cell death. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli. Amino Acids. Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.

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Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol Rev. Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders. Trends Neurosci. Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses. Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ.

Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochem Pharmacol. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat Genet. Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K ATP channels. Blood Flow Metab. Fruits and vegetables in the prevention of cellular oxidative damage.

Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid. Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxid Redox Signal.

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Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. Micronutrients and Alzheimer's disease.

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Proc Nutr Soc. Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system. Exp Neurol.


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